The Shvabe holding of the Rostec State Corporation is creating a gas-liquid artificial lung ventilation device (GZhIVL), which will save the lives of premature babies with insufficient opening of the lungs. The layout of the device has passed preliminary tests, preparations are underway for its experimental testing.
One of the main causes of death in premature infants is bronchopulmonary dysplasia, which occurs when the lungs are insufficiently opened and requires special respiratory support regimens, incl. using liquid ventilation. In the new apparatus "Shvabe" the usual module for the regeneration of respiratory fluid based on a chemical sorbent has been replaced by a module for vacuum desaturation.
“Reducing infant mortality is a major public health challenge. Thanks to innovative treatments and new types of equipment, this figure is now at an all-time low. The new gas-liquid lung ventilation device will provide new opportunities to save the lives of premature babies with bronchopulmonary dysplasia, one of the main causes of death among newborns. We expect that the product will receive registration from the Ministry of Health in 2024, after which such devices will begin to arrive in Russian medical institutions,” said Oleg Yevtushenko, Executive Director of Rostec.
At the moment, Shvabe specialists are carrying out work to modernize the GZhIVL experimental device for adults already created at the first stage of the project by installing a new desaturation module on it, which allows you to effectively and safely remove carbon dioxide dissolved in the respiratory fluid and saturate it with oxygen. After that, the experimental testing of the GZhIVL device will take place and the registration of the product will begin.
“The economic effect of its introduction into clinical practice will be that doctors will be able to perform artificial lung ventilation using a smaller volume of the hydraulic circuit filled with expensive respiratory fluid,” commented Sergei Dmitrochenko, Deputy General Director of Shvabe.
Development work has made it possible to implement a number of original technical solutions that ensure patient safety in terms of preventing baro- and volutrauma. The GZhIVL device is planned to be used, among other things, for controlled hypothermia - cooling patients down to 30°C in order to reduce the effects of hypoxia that occurs during difficult labor.
The customer of the work is the Advanced Research Foundation. In 2020, the Fund successfully completed a project to develop liquid breathing technology, the results of which confirmed the possibility of using gas-liquid artificial lung ventilation to ensure sufficient gas exchange due to the gas-transport function of a special respiratory liquid formulation and operating modes of an experimental model of a gas-liquid lung ventilation apparatus. The results of the project confirmed the feasibility of the technology, and the experiments made it possible to form a scientific and technical reserve for the creation of promising medical equipment and non-alternative methods of treatment.
“This method will be used in medicine to provide care in critical conditions, both in adults and newborns, for the treatment of severe bronchopulmonary diseases, as well as for the rapid cooling of the human body during emergency brain surgery,” said the Deputy General Director of the Fund for Advanced research Vitaly Davydov.
In cooperation with the expert community, the stages of introduction of treatment methods based on gas-liquid artificial lung ventilation into clinical practice were determined. It includes the creation of a finished dosage form of a respiratory fluid with desired properties and a gradual transition from bronchoalveolar lavage to automatic hardware gas-liquid artificial lung ventilation. At each stage, it is planned to conduct preclinical studies in leading scientific and clinical organizations of the country.
September 15, 2022 in Moscow on the basis of the Federal State Budgetary Institution Scientific Research Institute of Occupational Medicine named after Academician N.F. Izmerov” (NII MT), a laboratory of the Advanced Research Foundation was opened to develop a method of gas-liquid artificial lung ventilation. The project is being developed by specialists from the Ural Optical and Mechanical Plant. E.S. Yalamov (UOMZ) with the support of the Center for Obstetrics, Gynecology and Perinatology. IN AND. Kulakov.
bbabo.Net